In ALS pathology, certain proteins have been more implicated than others, e.g., SOD1 (Cu-Zn superoxide dismutase 1), TAR-DNA-binding protein-43 kDa (TDP-43) and fused in sarcoma/translocated in sarcoma (FUS/TLS) (Shaw et al., 2001; Guerrero et al., 2016). Here, TARDBP is linked to amyotrophic lateral sclerosis.