TARDBP and amyotrophic lateral sclerosis: A similar approach has also been performed with focus on TDP-43 where it was found that the C-terminal prion-like domain, the region containing most of the ALS-linked mutations in TDP-43, was necessary for, and even increase, TDP-43 aggregation and toxicity (Johnson et al., 2008; Cushman et al., 2010).