INS and diabetes mellitus: In this study, though subjects carrying the GG genotype of rs2281939 (T228A polymorphism) of SORBS1 had lower BMI, they were more insulin-resistant with higher SSPG (Table 5), which may explain the higher risk of DM and earlier age at onset of DM in subjects with the GG genotype of rs2281939 (Tables 3 & 4).