The aim of this study was to exam the result of previous study and explore whether novel genetic variants of SORBS1 are associated with parameters of glucose homeostasis, prevalence of diabetes mellitus (DM), and age at onset of DM in a cohort of ethnic Chinese family members from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) study with 5 years of follow-up. This evidence concerns the gene SORBS1 and diabetes mellitus.