ERBB2 and breast cancer: In conclusion, neoadjuvant treatment with the potential biosimilar PF-05280014 administered in combination with docetaxel and carboplatin demonstrated non-inferiority in pharmacokinetics and comparability in efficacy, safety and immunogenicity when compared with trastuzumab-EU in combination with docetaxel and carboplatin in patients with operable HER2+ breast cancer.