In fact, when HSCs of MM patients were incubated with VEGF, FGF-2 and insulin-like growth factor (IGF), cells differentiate into endothelial cell-like cells expressing typical endothelial markers, such as factor VIII-related antigen (FVIII-RA), VEGFR-2 and VE-cadherin, and form capillary-like networks in vitro [21]. This evidence concerns the gene VEGFA and Miyoshi myopathy.