Two apoptosis-related genes were up-regulated in MM endothelial cells: BNIP3 belongs to the Bcl-2 family, and IER3 is a member of the “immediate early response gene” family induced by the anti-apoptotic factor nuclear factor κB in response to the tumor necrosis factor-α and ligand-mediated FAS. The gene discussed is BNIP3; the disease is Miyoshi myopathy.