VEGFA and Miyoshi myopathy: Roccaro et al. [68] demonstrated that microRNA-15a/-16, which are downregulated in MM plasma cells as compared to normal cells, exert an antiangiogenic activity, reducing VEGF secretion from MM cells at the protein level, thereby reducing MM plasma cell proangiogenic activity on endothelial cells and these data were further confirmed in vivo in the CAM assay.