Furthermore, patients with elevated liver tests at the time of a CD diagnosis require an extended search for other liver disease, i.e., when the clinical evaluation is not consistent with celiac hepatitis, such as: (1) elevated transaminases levels >5-time the ULN and/or AST/ALT > 1, (2) laboratory signs of cholestasis (i.e., elevated gamma glutamyl transferase, alkaline phosphatase of liver origin, and/or bilirubin), (3) symptomatic liver disorder and/or (4) physical and ultrasonographic signs suggesting a liver disorder. This evidence concerns the gene GPT and liver disorder.