Additionally, the smaller 10 nm PVP-coated nanosilver elicited stronger nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factor and antioxidant response element (ARE) related gene activation, while than the larger 75 nm PVP-coated nanosilver activated more genes related to mitochondrial dysfunction, DNA damage, and kidney damage [69]. This evidence concerns the gene NFE2L2 and Nephropathy.