In the present study, the aim was to obtain conjugated gold nanoparticles to evaluate its effect into human pancreatic cells: MIA PaCa-2, a pancreatic cancer cell line that express high levels of HER2/neu and EGFR [21,29,30], and hTERT-HPNE, an immortalized human pancreatic duct epithelial cells [31]. Here, ERBB2 is linked to pancreatic neoplasm.