As shown in Figure 1A,B, we found that treatment of CRC cells (HCT116 and HCT116R) with resveratrol (5 μM) alone blocked (p < 0.05) or resveratrol (5 μM) and co-treatment with 5-FU (1 nM) and TNF-β (10 ng/mL) or TNF-α (10 ng/mL) enhanced dramatically inhibition of the invasion ability of HCT116 and HCT116R cells through the alginate-based matrix compared to untreated cells (Figure 1A,B). Here, TNF is linked to colorectal carcinoma.