In order to get more insights into the functional suppressive roles of resveratrol in TNF-β-induced tumor malignity in CRC cells and in the process of the synergistic effect with 5-FU in relation to epithelial-to-mesenchymal transition (EMT), we have examined the expression of EMT-associated signaling molecules, such as E-cadherin, vimentin and transcription factor slug (Fig. 5C-D). The gene discussed is VIM; the disease is colorectal carcinoma.