To explore the underlying molecular mechanism of how resveratrol suppresses TNF-β-induced malignancy of CRC cells and chemosensitizes to 5-FU, we investigated whether the effects of resveratrol on CRC cells in TNF-β-induced pro-inflammatory alginate tumor microenvironments was associated with the inhibition of NF-κB activation and NF-κB-regulated gene products involved in tumor metastasis. The gene discussed is NFKB1; the disease is colorectal carcinoma.