Overall, our results suggest that resveratrol may suppress multiple pathways activated by TNF-β, modulate the NF-κB-regulated gene expression, CSC formation and increase apoptosis in CRC cells and chemosensitizes CRC cells to 5-FU in TNF-β-induced inflammatory tumor microenvironment (Figure 6). Here, NFKB1 is linked to colorectal carcinoma.