LTA and colorectal carcinoma: Interestingly, it was noted that there was little or no effect of 5-FU with or without TNF-β on HCT116R cells, indicating that HCT116R cells are resistant to 5-FU and underlining the important role of TNF-β-induction on the malignant potential of human CRC cells and the chemosensitisation potential of resveratrol even in a TNF-β-induced pro-inflammatory microenvironment (Figure 4I,II).