To explore the underlying molecular mechanism of how resveratrol suppresses TNF-β-induced malignancy of CRC cells and chemosensitizes to 5-FU, we investigated whether the effects of resveratrol on CRC cells in TNF-β-induced pro-inflammatory alginate tumor microenvironments was associated with the inhibition of NF-κB activation and NF-κB-regulated gene products involved in tumor metastasis. Here, NFKB1 is linked to neoplasm.