However, immunoblotting analysis of CRC tumor microenvironment cultures (HCT116 and HCT116R) treated with resveratrol alone or in combination with 5-FU or with TNF-β or with TNF-α showed marked suppression of vimentin, the transcription factor slug and induction of E-cadherin expression (Figure 5C,D). This evidence concerns the gene TNF and colorectal carcinoma.