Indeed, our laboratory has shown previously that the ability of the natural compound resveratrol to stimulate Sirt1 activity, to inhibit acetylation of p65 [44] and suppress NF-κB transcription correlates with a sensitization of CRC cells to 5-FU and to apoptosis (activation of capase-3) in TNF-β-mediated tumor inflammatory microenvironment, highlighting resveratrol/Sirt1 pathway serves as a tumor suppressor in CRC cells and can modulate the tumor inflammatory microenvironment induced by other agents. The gene discussed is SIRT1; the disease is colorectal carcinoma.