The combined treatment with resveratrol, 5-FU and/or with TNF-β or with TNF-α resulted in significant synergistic enhancement in inducing caspase-3 cleavage in HCT116 and HCT116R (Figure 5A,B) cells compared to control tumor cultures, suggesting that resveratrol increased TNF-β/5-FU-induced caspase-dependent apoptosis in CRC cells, rather than modulating TNF-β and/or 5-FU-induced NF-κB-regulated apoptotic genes. This evidence concerns the gene CASP3 and neoplasm.