In the case of C-reactive protein and coronary heart disease, the Mendelian randomisation estimates suggest that targeting CRP is unlikely to be a viable therapeutic target for the prevention of coronary heart disease.72 In contrast, when the Mendelian randomisation estimate has very wide confidence intervals that overlap the observational estimate and include the null (as in the case of dairy consumption and blood pressure),69 very little can be inferred from the Mendelian randomisation results. This evidence concerns the gene CRP and coronary artery disorder.