The rationale for this is based on the observations that not only can TIIA significantly promote BMSCs migration and recruitment by the up-regulation of CXCR4 in a myocardial ischemia model [16, 17] but also that in the SCI model, TIIA administration can effectively attenuate the inflammatory response, apparently resulting in a decreased number of activated astrocytes and decreased glial scar formation [19]. This evidence concerns the gene CXCR4 and myocardial ischemia.