FeNO was used as the primary measure to monitor the anti-inflammatory activity of FF/VI as it is a validated biomarker of Type 2 inflammation in asthma, highly sensitive to ICS therapy, and, unlike alternative biomakers such as sputum or blood eosinophils or serum periostin, can be repeated twice daily in both a home and inpatient setting [11]. The gene discussed is POSTN; the disease is asthma.