, it was reported that cytochromic acidification to apoptotic stimuli associated with the mitochondria such as staurosporine and ultraviolet light and cytochrome-c expression stimulated caspase activation and mitochondrial depolarisation and therefore, with the impairment of intracellular homeostasis and metabolism by drugs which reduce the pHi in cancer cells, apoptosis is expected to form in cancer cells.44 Here, CYCS is linked to cancer.