In a multivariate longitudinal analysis including age at necropsy, sex, SIV/SHIV plasma VL, CD4 counts, and gammaherpesvirus PBMC viral loads, SIV/SHIV plasma VL and RLCV DNA viral load in PBMCs were independently associated with odds of developing cancer but RRV and RFHV DNA viral loads in PBMCs were not. This evidence concerns the gene CD4 and cancer.