It was observed that the mean values of FBS, TG, total cholesterol (TC), HDL, low density lipoprotein (LDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), fasting Insulin and HOMA-IR were significantly increased in OSA with NAFLD group as compared to controls. The gene discussed is INS; the disease is obstructive sleep apnea syndrome.