We hypothesized that the CRP rs1130864 (1444C/T), IL-6 s1800795 (-174G/C) and LEPR rs1137101 (Q223R) polymorphisms which may play an important role in inflammation and this may affect the susceptibility to OSA and NAFLD in non-diabetic Asian Indians. This evidence concerns the gene LEPR and obstructive sleep apnea syndrome.