GSN and liver disorder: Gelsolin, a Ca2+‐regulated actin filament severing and capping protein, is a highly conserved, polyfunctional regulator of cell structure and metabolism.33 Previous research demonstrated that gelsolin was prevalently expressed in a variety of cells and was decreased in various liver diseases,.34 However, ROC analysis (AUC: 0.697; 95% CI 0.626–0.768 in AIC and AUC: 0.770; 95% CI 0.704–0.837 in AIH) showed gelsolin was also not an ideal diagnostic indicator.