Altered expression of MUC2 has long been documented in patients with colorectal cancer and correlated with metastasis and prognosis.37, 38, 39, 40 We therefore hypothesize that aberrant O‐glycosylation may contribute to tumorigenesis and metastasis of cancer cells by affecting MUC2 expression and function. The gene discussed is MUC2; the disease is colorectal cancer.