C1GALT1C1 and pancreatic neoplasm: Cosmc is required for accurate folding of T‐synthase in ER.15 Our results were comparable with a recent report that Cosmc hypermethylation was a prevalent mechanism for aberrant expression of immature truncated O‐glycans in pancreatic cancers.35 However, other mechanisms such as Golgi to ER relocation of the enzymes initiating O‐glycosylation46, 47 and altered expression of enzymes responsible for sialylation cannot be excluded and may play distinctive roles under different circumstances,48 which await further exploration.