The results showed that LS174T cells transfected with WT Cosmc (Tn‐negative) exhibited a prominent suppression in growth and migration properties as compared with blank vector‐transfected cells that still express Tn antigen (Tn‐positive) (Figure 4), suggesting that lack of proper O‐glycosylation enhances cancer cell proliferation and migration. The gene discussed is C1GALT1C1; the disease is cancer.