Loss of Dsg2 is embryonically lethal (Eshkind et al., 2002) while mutations in Dsg2 (Awad et al., 2006) and Dsc2 (Syrris et al., 2006) cause arrhythmogenic right ventricular cardiomyopathy (ARVC), a hereditary heart disease. This evidence concerns the gene DSC2 and Arrhythmogenic right ventricular dysplasia.