CUL3 and cancer: The central role of CUL3 in metazoan development (McGourty et al., 2016; Singer et al., 1999; Werner et al., 2015), and its frequent misregulation in cancer, autism, or hypertension (Hayward et al., 2017; Northcott et al., 2017; Rape, 2018), implies that this E3 ligase needs to be under strict control.