Several studies have demonstrated that the expression of MNF2 decreased in the kidney, myocardium and retina in diabetes patients, which was associated with excessive apoptosis regulated by BAX/BCL‐2 expression.42, 50, 51 Recently, Robb et al53 have shown that RES stimulates mitochondrial fusion and cell growth through mitofusin activity. The gene discussed is BAX; the disease is diabetes mellitus.