1991). In obesity, a diminished lipid‐buffering capacity of the adipose tissue might lead to ectopic lipid deposition in skeletal muscle, liver, and heart and has been linked to insulin resistance in these tissues (Stinkens et al. 2015). Next to insulin, angiopoietin‐like protein 4 (ANGPTL4) has emerged as an important regulator of in vivo LPL activity in adipose tissue and skeletal muscle, and thereby as a potent modulator of lipid metabolism (Dijk and Kersten 2014). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.