To investigate whether ASK1 inhibition can prevent the development of progressive crescentic glomerulonephritis, we examined the NTN model in susceptible inbred WKY rats.31, 32 Compared to SD rats, induction of NTN in WKY rats causes less severe glomerular injury on day 1, but WKY rats reliably develop crescentic lesions by day 14.31, 32 Induction of NTN in vehicle‐treated WKY rats resulted in proteinuria on days 7 and 14, together with significant renal function impairment on day 14 (Figure 3A,B). The gene discussed is MAP3K5; the disease is crescentic glomerulonephritis.