The current study showed high sensitivity of 99mTc-α-MSH imaging for both primary lesion and lymph node involvement (75% and 92%); however, the detection rate for distant metastasis was low (25%) which is remarkably less than conventional imaging techniques such as MRI with sensitivity of 86.9-100% for brain metastasis (15), computed tomography (CT) with 93% sensitivity for pulmonary metastasis (16) and 94% detection rate of 18F-FDG PET/CT for distant metastasis of malignant melanoma (17). Here, STAMBP is linked to melanoma.