The patient in which the c.-458 G>T variant was identified suffered a familial LVNC and was shown to be negative for mutations involving either of the genes most commonly associated with LVNC (TAZ, DTNA, STN, SCN5A, CSX/Nkx2.5, FKBP12, and LDB3). The gene discussed is NKX2-5; the disease is left ventricular noncompaction.