The 14-3-3ε isoform encoded by the YWHAE gene is involved in various processes and pathologies like Miller Dieke syndrome, periventricular heterotopias, corpus callosum hypoplasia, neuronal development and cardiac channel activity (77, 83–88) Recently it has been shown that mice lacking the YWHAE gene develop a left ventricular non-compaction cardiomyopathy (LVNC) phenotype with ventricular septal defects similar to the LVNC phenotype seen in humans (89). This evidence concerns the gene YWHAE and Abnormal cardiac septum morphology.