Given the number of helicase missense mutations linked to hereditary disorders or associated with cancer (Suhasini and Brosh, 2013), and following the lead of other clinically relevant targets [e.g., chemical rescue of p53 missense mutations (Bullock and Fersht, 2001)], the prospect of finding treatments or cures for certain chromosomal instability disorders arising from catalytic deficiencies in helicase proteins is plausible. Here, TP53 is linked to cancer.