WRN and cancer: Of those tested in cell-based assays, small molecule inhibitors of DNA unwinding catalyzed by WRN (Aggarwal et al., 2011, 2013b), BLM (Nguyen et al., 2013), and DNA2 (Liu et al., 2016; Kumar et al., 2017) all negatively affect proliferation of cancer cells and induce DNA damage and/or chromosomal instability.