DNA2 and bone osteosarcoma: NSC 105808 negatively affected proliferation of human bone osteosarcoma U2OS cells, and its anti-proliferative effect was suppressed by ectopic expression of DNA2 at a level 1.5–2.0-fold greater than endogenous DNA2, leaving the authors to propose that DNA2 is the target of the compound (Kumar et al., 2017).