Furthermore, whereas the silencing of p53 expression abrogated the induction of NOTCH1 by nutlin-3, the silencing of NOTCH1 enhanced the cytotoxic effect of nutlin-3, highlighting that NOTCH1 was an antiapoptotic target of p53 in both lymphoid and myeloid leukemia cells (137). The gene discussed is NOTCH1; the disease is myeloid leukemia.