The most frequent mutations in CLL were found within TP53, NOTCH1, SF3B1, MYD88, ATM, and BIRC3 genes involved in the regulation of key biologically relevant pathways such as DNA repair and cell-cycle control, NOTCH1 signaling, inflammatory pathways, Wnt signaling, and RNA splicing and processing (112). This evidence concerns the gene MYD88 and B-cell chronic lymphocytic leukemia.