Chromatin immunoprecipitation experiments performed on NOTCH1-ICD transfected CLL-like cells showed the direct binding of NOTCH1 to the MYC promoter and transfection with MYC-specific small interfering RNA reduced NPM1 expression, confirming that MYC was a transcriptional target of the NOTCH1 activation complex in CLL. Here, MYC is linked to B-cell chronic lymphocytic leukemia.