HSCs and the early hematopoietic progenitors of CLL patients also carry mutations in SF3B1, BRAF, EGR2, MYD88, and NFKBIE genes that are known to be mutated not only in CLL but also in other hematological malignancies (123–125). The gene discussed is NFKBIE; the disease is B-cell chronic lymphocytic leukemia.