TP53 and B-cell chronic lymphocytic leukemia: Features predicting CLL outcome include somatic mutations of the immunoglobulin heavy chain variable (IGHV) genes, expression of CD38 and ZAP-70 surrogate markers, identification of chromosomal abnormalities (deletions of chromosome 13q, 17p, and 11q, and trisomy 12), and recurrent mutations in TP53, NOTCH1, and SF3B1 genes (5).