Another important mechanism by which constitutive NOTCH1 signaling promotes CLL cell survival is by sustaining the expression of the antiapoptotic myeloid cell leukemia 1 (MCL-1) protein and the activity of the translational regulator eukaryotic translation initiation factor 4E (eIF4E) (152), which are both implicated in CLL pathogenesis (161, 162). This evidence concerns the gene EIF4E and B-cell chronic lymphocytic leukemia.