Various methods to induce lung damage similar to human IPF are available by using chemicals (BLM, peplomycin, fluorescein isothiocyanate, vanadium pentoxide, trinitrobenzene sulfonic acid), growth factor gene over-expression (TGF-β, IL-1β, IL-13, etc.)and inorganic particles (silica, asbestos). The gene discussed is IL1B; the disease is idiopathic interstitial pneumonia.