Second, a panel of IL-6-targeting agents, such as Siltuximab (chimeric anti-IL-6 Ab) (56), Sirukumab (fully human anti-IL-6 Ab) (57), Clazakizumab (humanized anti-IL-6 Ab) (58), Olokizumab (humanized anti-IL-6 Ab) (59), Sarilumab (fully human anti-IL-6R Ab) (60), and tocilizumab (61), are in different stages of clinical trials and are promising or have been approved for clinical RA treatment as replacement in a case of anti-TNF therapy failure (62). This evidence concerns the gene IL6 and rheumatoid arthritis.