The interpretation of sepsis as collapsing tolerance and resistance responses obtains increasing support by recent experimental data, in which mTOR and AMPK, as their master regulators, play central roles: For example, mortality of septic mice could be drastically decreased after treatment with the specific mTOR inhibitor rapamycin (50) and the mTOR–HIF1alpha pathway is required for metabolic activation of trained monocytes (51). Here, MTOR is linked to Sepsis.