CD8A and infection: In support of our initial observations that the elderly adults had less of the public A2+M158 TCR signatures (40), our new analyses encompassing age, tissue compartment, and infection, showed that aging had the greatest impact on memory A2+M158+ CD8+ T cells repertoire, leading to a reduced frequency and lower probability of TCR clonotypes presenting the TRAV27/TRBV19 TCRαβ signatures.