To date, our knowledge of human influenza-specific CD8+ TCRs has been mainly focused on the HLA-A*02:01-restricted immunodominant M158–66 (A2+M158) epitope (7, 34–42), as HLA-A*02:01 is the most common HLA class I allele expressed at 1–54.5% (43) across different ethnic groups worldwide. Here, CD8A is linked to influenza.