TRAT1 and familial Mediterranean fever: Separate from this is the gene responsible for another inflammatory disease: familial Mediterranean fever (FMF), designated MEFV, which encodes an inflammasome pyrin containing domain of purin (PYD), TRIM, and B30.2 and is activated by bacterial toxins like Clostridium difficile, toxin B (TcdB), and C3 toxins (10).