These pathways also overlap, for example, ubiquitination of ENaC promotes ENaC endocytosis (Wiemuth et al., 2007; Zhou et al., 2007), and Liddle’s syndrome mutations in ENaC prevent NEDD4-2 binding, thereby reducing ENaC ubiquitination and endocytosis (Lu et al., 2007; Zhou et al., 2007). The gene discussed is NEDD4L; the disease is Liddle syndrome.