Considering the TCGA datasets and our meta-analysis, we identified correlation between high HMGA2 expression and head and neck cancer, pancreatic ductal adenocarcinoma, ccRCC, hepatocellular carcinoma, esophageal adenocarcinoma and ovarian carcinoma, except breast cancer and gastric cancer. Here, HMGA2 is linked to nonpapillary renal cell carcinoma.