Recently, increasing evidences have suggested that HMGA2 protein could participate in aggressive tumor growth (Peng et al., 2008; Hristov et al., 2009), stem cell self-renewal (Nishino et al., 2008; Tzatsos and Bardeesy, 2008), DNA damage response (Li et al., 2009), and tumor cell differentiation (Shell et al., 2007). The gene discussed is HMGA2; the disease is neoplasm.