Conversely, our analysis of a dataset obtained from the BioGPS database in which normal mouse astrocytes were incubated with brain slices from a beta-amyloid overexpressing mouse model of Alzheimer's disease (Kurronen et al., unpublished, dataset available from http://ds.biogps.org/?dataset=E-GEOD-29317&gene=111174) revealed that TAAR1 RNA expression was reduced relative to cells incubated with normal brain slices, and this difference could not be accounted for by age or developmental stage. Here, TAAR1 is linked to Alzheimer disease.