Our previous work also demonstrated that CIG attenuated tau hyperphosphorylation partially by enhancing PP2A activity in an AD-like cell model (Yang et al., 2013), and inhibited the demethylation of PP2A catalytic subunit C in the hippocampus of rat model induced by intracerebroventricular injection with OA (data not shown). The gene discussed is MAPT; the disease is Alzheimer disease.