Alternatively, convulsions in C. elegans can also be induced by mutations in the lis-1-allele (pnm-1), a defect in γ-aminobutyric acid (GABA) transmission (unc-25 and unc-49 mutants) or by PTZ and RNAi treatments in roundworms with depleted LIS1 pathway compounds (NUD-1, NUD-2 and DHC-1, CDK-5, CDKA-1) (Pandey et al., 2010). Here, CDK5 is linked to convulsion.