MAPT and Alzheimer disease: These abnormal processes can lead to accumulation of Aβ in the brain and intraneuronal aggregation of hyper-phosphorylated tau protein, both of which are hallmarks of AD (Oddo, 2008; Riederer et al., 2011; Morawe et al., 2012; Hong et al., 2014; Gentier and van Leeuwen, 2015; Gadhave et al., 2016).