MAOB and Alzheimer disease: Similarly, region-specific changes in MAO-B activity in the AD brain have been observed (Adolfsson et al., 1980; Oreland and Gottfries, 1986) and MAO-B-positive astrocytes have been localized to the amyloid plaque in human brain (Saura et al., 1994) as well as in the brain of a mouse model of AD (Kim et al., 2016).