Recently, two studies has evaluated the association of expression quantitative trait loci (eQTL) SNPs in lncRNA AC016683.6, which located in the upstream region of PAX8 gene and could alter the expression of PAX8, with the susceptibility of cervical cancer [29] and the prognosis of hepatocellular carcinoma [30]. This evidence concerns the gene PAX8 and hepatocellular carcinoma.