TP53 and neoplasm: Particularly, Kanteti et al. [27] reported that PAX8 is overexpressed in non-small cell lung cancer (NSCLC), whereas PAX5 protein is predominantly expressed in small cell lung cancer (SCLC) by analyzing the expression profile of the PAX gene family, and speculated that PAX8 is likely to interfere with p53 transcription and contribute to the development of tumor.