In neurodevelopmental disorders, it is linked to under-or over-expression of MECP2 gene, such as in RTT and MECP2 duplication syndrome (MDS), where isoprostanoids formation have been shown to be specifically related to different MECP2 gene mutations [25,26,52,57,58,59] (Table 1). Here, MECP2 is linked to neurodevelopmental disorder.