Similarly, in a prospective study of 120 patients with CKD, Dou et al. [68] demonstrated that serum IAA was an important predictor of mortality and CVD events after adjusting for age, gender, cholesterol, systolic and diastolic BP, smoking, CRP, phosphorus, BMI, albumin, history of CVD, PCS, and IS, and remarkably, after adjusting for CKD stages as well. This evidence concerns the gene CRP and chronic kidney disease.