Roles of epigenetics in cerebral ischemia have also been reported, as inhibiting histone deacetylase 2 (HDAC2) promotes functional recovery [30,31] and protection against ischemic insult by inhibiting DNA methylation after treatment with a DNA methyltransferase (DNMT) inhibitor, 5-aza-2′-deoxycytidine (5-Aza-dC) [17,18,20]. Here, DNMT1 is linked to Cerebral ischemia.