To assess the effects of TST and DNA methyltransferase (DNMT) inhibitor 5-Aza-2′-deoxycytidine (5-Aza-dC), we treated the contralesional cortex of rats, carrying a photothrombotic ischemic stroke unilateral lesion eight weeks after injury, with TST. This evidence concerns the gene DNMT1 and ischemic stroke.