TFF1 hyper-expression or exogenous addition on gastric cancer cells led to the reduction of E-cadherin and of other epithelial markers, such as cytokeratins-8 and -18, and to the increase of mesenchymal markers, such as vimentin, and upregulation of significant transcription factors of EMT, such as Snail, ZEB1 and Nanog. The gene discussed is CDH1; the disease is gastric cancer.