TFF1 hyper-expression or exogenous addition on gastric cancer cells led to the reduction of E-cadherin and of other epithelial markers, such as cytokeratins-8 and -18, and to the increase of mesenchymal markers, such as vimentin, and upregulation of significant transcription factors of EMT, such as Snail, ZEB1 and Nanog. This evidence concerns the gene ZEB1 and gastric cancer.