Moderate alcohol intake, either red wine (30 g of alcohol per day), the same amount of dealcoholized red wine, and gin (same amount of alcohol), consumed for four week periods demonstrated that red wine and dealcoholized red wine consumption decreased plasma insulin and the homeostasis model assessment of insulin resistance, therefore, it was concluded that red wine is protective against type 2 diabetes in association with an improved insulin sensitivity. This evidence concerns the gene INS and Insulin resistance.