Preeclampsia and FGR share a number of associations with biomarkers of placental function, including low first trimester of pregnancy-associated plasma protein A (PAPP-A), high second trimester α-fetoprotein (AFP) in maternal serum (23), and high resistance patterns of uterine artery Doppler flow velocimetry (24, 25). The gene discussed is AFP; the disease is preeclampsia.