CDH1 and breast ductal adenocarcinoma: The inverse association between cell individualization and E-cadherin expression in the spheroid implantation model in vivo is consistent with the observed increased single-cell release in 3D organotypic culture of MMT compared with 4T1 spheroids (Fig. S2D), and in patient samples from human lobular compared with ductal breast carcinoma (Fig. S2E) (Khalil et al., 2017).