To elucidate the impact of a defective NRF2‐dependent response in the pathogenesis of adrenoleukodystrophy, we decided to treat Abcd1− mice with DMF, a classical activator of NRF2 (Linker et al, 2011; Scannevin et al, 2012). The gene discussed is NFE2L2; the disease is X-linked adrenoleukodystrophy.