In this study, we observed normalization in the gene expression of Nfkb2 transcription factor and pro‐inflammatory cytokines like Tnfa, Ccl5, Cxcl10, and Ccr6, concomitant with an increase in the anti‐inflammatory cytokines Il10 and Chil3. This DMF effect is consistent with previous reports showing an in vivo anti‐inflammatory effect in the experimental autoimmune encephalomyelitis animal model (Schilling et al, 2006). This evidence concerns the gene NFKB2 and experimental autoimmune encephalomyelitis.