Inactivation of the NRF2 pathway is not a phenomenon limited to X‐ALD, but is reported in several neurodegenerative disorders including Alzheimer's disease (Ramsey et al, 2007; Kanninen et al, 2008), amyotrophic lateral sclerosis (Sarlette et al, 2008), Friedrich's ataxia (Paupe et al, 2009; Shan et al, 2013), and experimental autoimmune encephalomyelitis mouse models (Morales Pantoja et al, 2016). Here, NFE2L2 is linked to amyotrophic lateral sclerosis.