Visualization of the mass cytometry data obtained from a cryopreserved synovial biopsy sample using the dimensional reduction tool viSNE [27] revealed clear discrimination of synovial fibroblasts (cadherin-11+), endothelial cells (VE-cadherin+), and immune cell subsets from cryopreserved RA synovial tissue (Fig. 4b). This evidence concerns the gene CDH5 and rheumatoid arthritis.