As shown if Fig. 5g, stably overexpression of SPOP-F133 L mutant markedly increased the mRNA expression of ATF2 downstream target genes involved in cancer cell proliferation and invasion, including SOX9, MMP9, and TGFB2, [35–37], but this effect was largely abrogated by ATF2 depletion. This evidence concerns the gene ATF2 and cancer.