CD274 and non-small cell lung carcinoma: In the KEYNOTE-010 trial, pembrolizumab prolonged OS and had a favourable benefit-to-risk profile in patients with previously treated PD-L1-positive advanced NSCLC [31], while in KEYNOTE-024, pembrolizumab was superior to chemotherapy as first-line therapy for advanced NSCLC with PD-L1 tumour expression ≥50% [32].