The HepaVac vaccine consists of an ‘off-the-shelf’ vaccine comprising 18 newly identified MHC-I and II tumour-associated peptides (TUMAPs) naturally processed and presented on primary tumour tissues from HCC patients (HLA peptidome), for the induction of tumour-specific CD4+ T helper cell and cytotoxic CD8+ lymphocyte effector and memory immune responses. This evidence concerns the gene CD4 and neoplasm.