CD274 and non-small cell lung carcinoma: In the phase II ATLANTIC study in heavily pre-treated patients with locally advanced or metastatic NSCLC, overall response rate (ORR) with anti-PD-L1 durvalumab was 7.5% (95% CI: 3.1–14.5) in patients with PD-L1 expression <25% and 16.4% (95% CI:10.8–23.5) in patients with PD-L1 expression ≥25% [28].