CD274 and non-small cell lung carcinoma: However, in the phase III MYSTIC trial (NCT02453282), the combination of first-line treatment with durvalumab and tremelimumab in previously untreated NSCLC patients did not meet the primary endpoint of improved PFS compared to standard of care in patients with ≥25% PD-L1 tumour expression (www.ascopost.com/News/57874).