Treatment of p18−/−; Brca1MGKO tumor cells including both type 1 and type 2 cells with AZD5363 significantly reduced the E2-enhanced number of cells and incorporation of BrdU (Fig. 6b, c and Additional file 8: Figure S8C), indicating that AZD5363 inhibits estrogen-enhanced proliferation of Brca1-deficient tumor cells. This evidence concerns the gene BRCA1 and neoplasm.