MKI67 and neoplasm: Consistent with the findings derived from p18−/−;Brca1MGKO tumor cells in vitro (Fig. 6b), we also detected that AZD5363 significantly reduced the number of Ki67 and Ck14 double-positive cells stimulated by E2 in p18−/−;Brca1MGKO tumors (Fig. 6g).